Prof. Parks Makhoahle is a recognised golden key recipient from Golden Key international Honour Society. He holds a BSc degree (Microbiology and Biotechnology), B.Med.Sc Hons (Medical Microbiology) and M.MedSc (Medical Microbiology and virology) from the University of Free State, and D HSc (Biomedical Technology) and PGDIPHE from the Central University of Technology.  

In quenching his thirst for education, he is currently registered for his second doctorate in educational studies and the interim Director of the Centre for Quality of Health and Living in the Faculty of Health and Environmental Sciences. Makhoahle’s recent research focuses on anti-cancer, splicing activity of natural products and genotoxicity and the use of natural products to prevent mycotoxin-induced carcinogenicity, pursuing research with researcher(s) from UFS, NHLS and WHO-Lesotho HIV hub initiative.  

When elaborating on his study, Prof. Makhoahle said “My research focuses on bioactivity of medicinal plants in particular, the African ginger exosome-like nanoparticles (AGELNs). They closely resemble the natural substrate of cancer enzyme inhibition and possess the ability to inactivate the enzyme by crosslinking with its active site. The overall aim is to develop a nutraceutical approach to identify exosomes-derived products that inhibits PDL1 expression in tumour cells. The most exciting part of this study is ‘gold standard’ GC-MS quantitative metabolomics in isolated exosomes and nutraceutical supplement could also be utilised to prevent or treat chronic lung diseases.” 

He mentioned that he chose the path of cancer research primarily out of passion. “From a young age, I was deeply moved by the stories of those affected by cancer and felt a strong desire to make a meaningful difference in the lives of those affected. This passion grew over time as I learned more about the complexities of the disease and the challenges faced by researchers in this field. My intrinsic motivation and commitment to finding solutions and improving treatments for cancer patients have driven me to dedicate my efforts to this important area of study, which was also influenced by several other factors,” he said. 

His other factors included Personal Encounters, Academic Curiosity, Inspirational Mentors, and the desire to make a difference. “Witnessing the struggles of friends and family members who have battled cancer deeply impacted me. Their experiences fuelled my determination to contribute to the fight against this devastating disease. My academic background and fascination with biology and medical sciences naturally led me towards exploring this study. The complexity and urgency of finding better treatments and understanding cancer at a molecular level captivated my interest”. 

“Along my educational journey, I encountered inspiring mentors and researchers whose work in cancer research was groundbreaking. Their guidance and passion further solidified my decision to pursue this path. The desire to make a tangible impact on people's lives has always been a driving force for me, so this cancer research presented a unique opportunity to contribute to advancements that can save lives and improve the quality of life for patients,” added Makhoahle . 

His ultimate goal is to advance scientific knowledge and contribute to the scientific community's understanding of cancer, particularly in identifying new biomarkers and developing innovative therapies. He also wishes to improve cancer patient outcomes by helping to develop more effective and less toxic treatments. Furthermore, he aims to raise awareness through his research and outreach efforts, and mentor future cancer researchers. 

“I intend to raise awareness about cancer prevention, early detection, and the importance of research funding. I hope to see my research translate into real-world applications that can extend and enhance patients' lives. I also aspire to mentor and inspire the next generation of scientists, fostering a collaborative and supportive research environment.” 

He said that despite advances in chemotherapy for the treatment of cancer, factors such as costs, side effects and development of resistance to chemotherapy are major obstacles particularly in the global south. “This work promises novel ways and methods to target cancer utilising inexpensive natural products.”   

As a HPCSA registered medical Biological Scientist, he is also involved medical microbiology, virology (Hep B). He is supervising 9 master’s students, two PhD’s and has more than 30 publications and a book chapter in peer reviewed journals under his belt.  

He is a reviewer of NRF, as well as the multi–Vice-Chancellor’s Awards holder. In 2024, he was amongst the 52 selected candidates as part of TAU 5 fellowship from all 26 universities, he was also instrumental in the establishment of one of the CUT’s state-of-the-art Biochemistry and Tissue Culture facility - The Centre for Quality of Health and Living (CQHL).