Meet Prof. Polo-Ma-Abiele Hildah Mfengwana, who is an Associate Professor and the Head of the Health Sciences Department at CUT. Her field of research is on the preclinical research of anticancer drugs derived from medicinal plants and also in Immunohematology research. Her academic focus is on discovering and developing novel therapeutic agents that harness the unique properties of indigenous flora to combat cancer.

Her research focuses on the identification and characterisation of bioactive compounds in medicinal plants, assessing their efficacy and mechanisms of action against various cancer cell lines. “This work not only contributes to the scientific understanding of traditional medicine but also bridges the gap between natural products and their potential applications in modern oncology.”

Prof. Mfengwana has led several major initiatives, notably, the establishment of a collaborative research network that engages local traditional herbalists, botanists, and organic chemists from other Universities (Nelson Mandela University and National University of Lesotho). “This initiative not only supports sustainable harvesting practices but also ensures that knowledge exchange benefits all stakeholders, particularly in enhancing the economic and health prospects of local communities,” she said.

Her notable accomplishments encompass securing substantial funding for her pioneering research projects, mentoring several postgraduate students, and enhancing the scientific community's knowledge through her publications in esteemed journals. Her commitment to advancing this field is further evident by her completion of the course in Manufacture and Registration of Herbal and Cannabis-Based Medicines, offered by the University of Pretoria. This achievement highlights her relentless pursuit of excellence and innovation, enriching her expertise in developing scientifically validated medicinal products. Currently, she is involved in the development of a chemopreventive treatment aimed at supplementing existing therapies, which is in the process of registration with the South African Medical Research Council (SAMRC). Additionally, she is conducting preclinical studies to evaluate the in vivo anticancer activity of specific plants that have demonstrated promising results in preliminary in vitro tests.

Prof. Mfengwana’s efforts aligns with the university’s strategic vision of promoting research that has real-world applications and societal impact. Through her pioneering work, she contributes to the university's mission of leading in sustainable and innovative healthcare solutions, particularly in the realm of cancer research.

Her dedication to the field and the impact made on the development of new anticancer therapies, has established her as a key figure in her department and an inspiration to both her colleagues and students.

Uploaded: 26 March 2025